Providing Pure Gas and Air to BioProcess Units: Part Two

December 7, 2018 by Karl Lutkewitte

Providing Pure Gas and Air to upstream and downstream BioProcess units is critical business.  Here are a few things we have learned over the years that might help.

If you are measuring particulate in an air or gas stream……..

  • Don’t specify NPT connections if you are worried about particulate.  Particulates can clog sterile filters, and, more importantly are a final product quality concern.  If you are testing Compressed gas for particulate, NPT connections increase the probability of failing the test.  The act of threading a Tube fitting into the inlet, outlet or gauge port of the valve during installation creates metal particulate!  And, if you use Teflon tape, you will create Teflon particulate.  Sanitary clamp connections should only be used.
  • Specify certified Clean for Oil Free, or O2 Clean-Assemble dry* when ordering these valves.  The steps involved in cleaning the valves remove lubricant and particulate from wetted parts. Lubricants atomize in the presence of high velocity gas, and can add to particulate loads.
  • Make sure your valve is sized correctly. (See also Part One in this blog series). Oversized valves, which operate close to the seat, are more likely to operate in an unstable manner, with the trim components constantly adjusting in an attempt to regulate pressure. That increased frequency of movement increases wear over time, and  component ware is another source of particulate.

* Some manufacturers allow you to specify O2 Clean – Assemble dry.  That means that no lubricants are used on any component that comes in contact with clean air or gas. But, the wearing components outside of the process envelope can be lubricated with an O2 safe lubricant like KrytoxTM, without fear of lubricant atomization.


Karl Lutkewitte
Karl Lutkewitte, Steriflow Valve Product and Sales Manager

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